Tumor rejection antigens of chemically induced sarcomas of inbred mice.
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چکیده
منابع مشابه
Fetal antigens shared as transplantation rejection antigens on chemically induced mouse and hamster sarcomas.
We have previously reported that two chemically induced sarcomas of BALB/c mice (MCA-1315 and -1321) contained common transplantation antigens which could be detected by immunization of normal BALB/c mice with irradiated tumor cells of each line. This cross-protection could not be detected in animals surgically cured of these tumor lines and challenged with a high dose of tumor cells, but it wa...
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Cultured cells of different chemically-induced C57BL/6N murine sarcomas produced variable amounts of infectious murine leukemia virus (MuLV) and contained proportional amounts of MuLV structural components as determined by radioimmunoassay. Monospecific antisera directed against the major MuLV glycoprotein (gp71), the major internal antigen (p30), and the ribonucleoprotein (p10) were capable of...
متن کاملFurther evidence of common antigenic properties in chemically induced sarcomas of mice.
The transplantability of five methylcholanthrene-induced sarcomas of C57BL/6 mice was tested by subcutaneous inoculation of quantitated tumor cell suspensions in variously immunized syngeneic recipients. All five tumors gave evidence of resistance in recipients that were immunized and challenged with the same tumor. There was no evidence of cross-resistance between these tumors when mice were i...
متن کاملExpression of a shared tumor-specific antigen by two chemically induced BALB/c sarcomas.
A tumor-specific antigen (TSA) expressed on the chemically induced BALB/c Meth A sarcoma and one of 22 other BALB/c sarcomas tested, CMS13, was detected in in vitro cellular and humoral assays. The distribution pattern of the TSA defined in a complement-dependent microcytoxicity assay by cytotoxic antibodies present in CMS13 antisera was similar to that detected by a cytotoxic T-cell clone, des...
متن کاملVirus-like particles in chemically induced sarcomas in high- and low-leukemia strains of mice.
Well-differentiated fibrosarcomas and anaplastic sarcomas developed in the s.c. tissues of four low-leukemia strains of mice (BALB/cf/Ki, Af/Ki, C3H/KÌand C3Hf/Ki) as well as two high-leukemia strains (AKR/Ki and C58/KÌ) following a single injection of benzpyrene (0.004 mg/g body weight) as young adults. The incidence of sarcomas was significantly less in both high-leukemia strains than that ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.10.3407